UNSIGHTED introduces a mechanic where your choices matter and have consequences. The game touches upon and delve into Alma’s backstory and relationships with other important characters. Essentially, the fate of her kind lies on her shoulders. Alma’s special because she received advanced programming and combat training. ![]() These shards will recreate a powerful sword that can destroy the plague infecting the automatons. After reuniting with old friends, Alma is tasked with retrieving five shards scattered throughout Arcadia. You play as Alma, an automaton created by a human doctor, who wakes up alone with no recollection of what has happened. Once they become UNSIGHTED, they lose their mind and succumb to madness. They have depleted their Anima, the source of their sentience, and become UNSIGHTED. In their place, a group of robots are building their last line of defence against the threat of rogue automatons. UNSIGHTED puts you in the world of Arcadia, a post-apocalyptic city where humans have ceased to exist. In-game Screenshot “The feeling of running out of time does an excellent job of creating tension and ultimately highlights the responsibility you have in determining the outcome of UNSIGHTED’s narrative.” It features excellent storytelling, challenging souls-like combat, beautiful pixel art, among a slew of other unique gameplay mechanics. ![]() It is an isometric action RPG with a Metroidvania twist, not unlike Eldest Souls. ![]() Even more so if it is one that takes inspiration from The Legend of Zelda and Hyper Light Drifter. Whenever one of these pops up I can’t help but want to try it out for myself. But every so often one appears that offers to blend two incredible titles to create something familiar yet wholly unique. There’s no shortage of indie pixel games nowadays.
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![]() You know how it usually goes, right? The most popular subgenre here is the one that involves a very interesting switcheroo (from a lady to a gay dude) in the movie. Those are supposedly 100% real and none of the men involved are bisexual or gay. Straight guys have been popular in gay porn for many years but lately, you're starting to see more and more "straight seduction" videos. Even though free gay porn movies with jacked-up studs are still racking up decent profits in the gay porn industry, these skinny guys are making MUCH more money currently. The dudes are really skinny and oftentimes effeminate because of that. The thinner the body, the hotter, right? That's why the "Skinny Men" genre is so popular. Now everyone wants to see true twinks fucking. The days of the popularity of gay muscle porn are seemingly over. Here is yet another porn genre that is pretty much everywhere at this point. Gay black sex has more than a few good years ahead of it and it looks like the gay porn industry is on board for at least the next several years. More people are coming to realize that black men are hotter and more desirable than the skin tones that the mainstream media (both mainstream movies and mainstream porn) would have us believe. He, for example, is enjoying the best year of his life in the gay porn industry. Lately, people started shifting their focus to guys like DeAngelo Jackson. Not too long ago, Roman Todd was THE go-to porn superstar. Caucasian and Hispanic porn superstars are getting up there in years and are no longer making nearly as many popular pornos as they used to, but black guys are taking their place! Black men are in such high demand in gay porn that they often become the main focus of the flick, and this often includes playing with multiple guys at once. It's no surprise! Everybody's real freaking tired of plain ol' white dudes. Nobody can get enough of the lean (and sometimes mean) Asian twinks! This may change next year, but for now, you should definitely enjoy this ethnicity-themed pornographic genre because it's everywhere. Even though there are still several other ethnic types that we are yet to see in popular gay porn, we think that Asian porn movies are the hottest as of late. All of that is reaching a point of saturation in some ways, as the demand for Asian gay porn has been great for the past few years. Asian MenĪsian men in general have become an increasingly popular choice among gay porn producers. Just choose a few and see if you really dig them. However, not all gay porn genres are as hot as you would like them to be. All too often one type of porn is popular not because the subject matter is more gratifying than the others, but because there's a certain shift that happened in the adult entertainment industry or some business decision made somewhere that causes one type of porn to go up in demand while another gets pushed to the side. By the way, we don't recommend that you check out EVERY genre because that would just be tiresome. Here is a list of gay porn genres to expect to see more of in the coming years. The list of popular genres changes on a regular basis but there are still some categories that are obviously always in demand. You can see this in the emergence of gay porn genres that reflect the current "It" areas of pop culture. It's obvious that the adult entertainment industry is very much in tune with the current fashions and social movements in popular culture. 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I do find it strange that there seems to be another small fan in the power brick somewhere when the Mac is off the EGPU shuts down but a faint fan noise can still be heard. Other reviews mention that the box fans are loud, I don't think that's true. I only needed to set up legacy AMD support in the purge-wrangler script, other than that its plug and play. The connector is not placed on the top but at the back, which had me worried if it would fit with the cable plugged in, but there is ample room as you can see from the pics. The GPU fits nicely in the enclosure and uses an 8 pin power connector. ![]() The banknotes which were released into circulation on September 13th are still catching the public’s attention with collectors looking to keep hold of the notes while they are still in good condition. The Aorus is the smallest EGPU enclosure, and the R9 Nano is probably the most computing power available in this small form factor. 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I sat there drinking slowly and watched her move about the house dusting and vacuuming. "I've got more house cleaning to do, and I hope to get it all done before it gets too late." "Just don't get to relaxed," she said,"still a lot that needs to get done." and she handed me my glass. "Thanks" I replied, and headed for the recliner. "Go sit in the living room, I'll bring you some ice water." she said. "Going to be a long, hot day." I told mother. The shorts were rather baggy, so I decided to forego underwear to help me better withstand the heat.Īfter the first hour working in the yard, the temperature climbed to around ninety degrees, so I headed inside for a drink of water and to take a little shelter from the sun. I deciced on gym shorts and a white tee shirt as the heat was predicted to be rather high. ![]() I felt my dick growing, so I stepped into my room. "Oh, no problem, I just need to know so I could dress accordingly." I answered while looking at her in the thin gown. She stopped and looked in my direction and said,"Mowing the grass for one, and maybe weeding the flower bed for me." To catch her attention and get a longer view of her, I asked," Well, what kind of yard work do you have in mind for me today?" In the hall I passed her, and she was still wearing her nightie, and I felt my cock stir again. After showering, I headed to my room wrapped in the towel around my waiste to dress for the day ahead. My thoughts turned to making myself more opportunities to see her body and thoughts of much else left my mind. "Damn" I thought," she's really got a nice bod on her." and I felt my cock twitching, and I went to the bathroom and removed my underwear and jerked off to the image of her that was fresh in my mind. I couldn't help but watch that ass as mom walked away. She let loose the covers and said,"Just get up, you're wasteing the days of summer away." and walked out of the room. Her nipples were very apparent to my eyes, and she was wearing black lace thigh riding panties. Through my eyes now wide open, I saw that she was still in her night gown, cream white and very thin. I was in my briefs and had my normal morning erection so I grabbed at the covers to try to keep my condition concealed. "O.K," she said,"but you need to get up and do some yard work." and jerked the covers off of me. "Mom" I shouted,"I'll start looking Monday, it's Saturday you know." Mother came into my room one morning and started,"don't you think you need to find a job soon?" she asked. Reality came back my way early in the summer, with a thought presented to me that I haden't giving much consideration, WORK."arghhh." Summer started out that year with thoughts of being lazy and having fun at whatever opportunity presented itself to me, swimming with friends, hanging out with the guys, and chasing girls,mmmm. It was my first summer knowing that I would not have to return to school in the fall. ![]() What follows is an accurate description of how things went after I finally finished High School. She had a very womanly shape about her, not too heavy and not to small the way I saw it, and fortunately for me I got to see it a lot. At around 5'6" tall and 36, 30, 38 dimensions, I found her to be very easy on the eyes. It was common for her to parade around in semi-transparent sleep clothes. All through my High School years from the age of fifteen to graduating at eighteen years of age, her state of dress was the focus of my jerk-off sessions. From the time I was old enough to like looking at the female body, It was evident that she liked to have hers looked at. Mother must have had a reason to dress as she did. The study found that 16% of patients with GEP-NETs, who were treated with Lutathera, experienced complete or partial tumor shrinkage. ![]() The Netherlands study gathered several patients with somatostatin receptor-positive tumors, including patients with GEP-NETs. They experienced a 79% reduction in death and cancer progression. The study concluded that patients who were treated with Lutathera lived substantially longer compared to those who only received the octreotide treatment. Researchers measured tumor growth after the course of the treatment, also known as progression-free survival. The study compared Lutathera treatment with a standard dose of octreotided LAR against a high-dose of octreotide LAR. NETTER-1, a Phase 3 study, was a randomized clinical trial which included patients with a severe form of somatostatin receptor-positive NETs. Studies įDA approval of Lutathera was ultimately supported by two clinical studies. As a result, studies found that 16% of patients being treated with Lutathera experienced either complete or partial tumor shrinkage. This mechanism effectively triggers apoptosis of cancerous tumor cells. After binding to the receptor, Lutathera enters the cell and uses its radioactive property to damage DNA. The dotatate binds to the GEP-NET positive somatostatin receptor cells commonly present on neuroendocrine tumors. Attached to the dotatate is the radioactive marker Lu-177, a radioisotope. Lutathera is a radioactive drug consisting of a tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) attached to the chelating agent tetraazacyclododecanetetra- acetic acid (DOTA). These receptors are commonly found on tumors located in the foregut, midgut, and hindgut. Lutathera is used to combat pancreatic and gastrointestinal cancers that do not respond well to common chemotherapeutical treatments namely for patients with somatostatin receptor-positive GEP-NETs. They are present in areas affected by pancreatic or gastrointestinal cancers specifically, the pancreas, stomach, intestines, colon and rectum. GEP-NETs are rare groups of cancer that continue to proliferate, regardless of initial therapy treatments. Lutathera is most notable as the first FDA approved peptide receptor radionuclide therapy (PRRT) to combat GEP-NETs. Its approval for Advanced Accelerator Applications was announced on January 26, 2018, by the US Food and Drug Administration. Lutathera, also known as lutetium Lu 177 dotatate, is a target treatment drug for patients with GEP-NETs. It was approved by the FDA in January 2018 for GEP-NET. It selectively targets over-expressed somatostatin receptors while also giving off gamma emissions to allow physicians to visualize where in the body both the drug and the tumor are. ![]() The company's lead product is LUTATHERA, a Lutetium Lu 177 dotatate labeled somatostatin analogue peptide, a theragnostic cancer product being developed to treat certain gastro-entero pancreatic neuroendocrine tumors ( GEP-NETs). See also: Peptide receptor radionuclide therapy The group's portfolio of radiopharmaceuticals includes radioactive agents for positron emission tomography ( PET) imaging as well as single-photon emission computed tomography ( SPECT) diagnostic products. Products ĪAA has a portfolio of diagnostic and therapeutic applications and products in the fields of Molecular Imaging and Therapy. ĪAA currently has a total of 31 sites in 12 countries, including: 19 production facilities in 8 countries (in Europe and the U.S.) that manufacture targeted radioligand therapies and precision imaging radioligands, and 6 sites with R&D activity. 2.1.5 Common Grade 3-4 Adverse ReactionsĪAA was created in 2002 by Italian physicist Stefano Buono to exploit a patent from the European Organization for Nuclear Research ( CERN). |
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